PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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Antioxidant and Antiinflammatory Activity of Vitex negundo.

Group I received distilled water and served as control. Cotton Pellet granuloma test: International Journal of Pharmacology, 2: It was identified actvity authenticated by an expert botanist from J.

It is also useful in actigity and blood disorders. Anti Inflammatory Activity The activity was evaluated by using carrageenan induced paw edema in rats. Antioxidant and antiinflammatory activity of Vitex negundo.

The anti-inflammatory activity in this dose of the test drug was comparable to phenylbutazone mg kg -1 PO.

Antioxidant and Antiinflammatory Activity of Vitex negundo

Mice were fasted overnight before the day of experiment and the liver was promptly excised after sacrificing the mice. The finding of present study strengthens the finding of Dharmasiri et al. The anti-inflammatory activity was studied by using carrageenan induced paw edema in rats.

Steam activlty of the leaves can be used as stomachic, purgative, febrifuge and antiemetic [ 8 ].

Therefore, it can be assumed that the inhibitory effect of the polyherbal extract of Vitex Negundo and Murraya Koenigii on carrageenan-induced inflammation could be due to the inhibition of the enzyme cyclooxygenaseleading to the inhibition of prostaglandin synthesis.


Immediately after injecting carrageenan. All animals were divided into five groups, six rats in each group. Cycloxygenase 1 and 2.

Carrageenin induced rat hind paw edema method: Leaves are applied externally to bruises and eruption [ 9 ]. The extract was filtered lnflammatory whatmann filter paper no.

Ascorbic acid protects lipid in human plasma and low density lipoprotein against activuty damage. Select your language of interest to view the total content in your interested language. After washing, tissue homogenate was prepared in 10 volumes of ice-cold potassium chloride by homogenizing for 15 min.

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The oxidative stress is the condition where Reactive Oxygen Species ROS generation exceeds endogenous anti-oxidant defense Sen, and it is well known that in chronic and sub-acute inflammation reactive oxygen species play an important role in modulating the extent of inflammatory response and consequent tissue and cell injury Robbin et al.

An infusion of the toasted leaves in used to ijflammatory vomiting [ 6 ]. The tissue damage then provokes inflammatory response by the production of mediators and chemotactic factors 4.

The effects were compared with phenylbutazone abti kg -1 orally in carrageenin induced hind paw edema method and ibuprofen mg kg Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction.

Antioxidant infflammatory of carotenoids. Khare CP Indian medicinal plants an illustrated dictionary. Footnotes Kulkarni, et al.: X 7 days, p. It belongs to the family Rutaceae [ 2 ].

The reduced level of MDA was taken as indicator of anti-lipoperoxidative activity, which can be taken as index of reduced oxidative stress. Oxygen toxicity and antioxidants: A mark was put on the leg at the malleolus to facilitate uniform dipping at subsequent readings.

The filtrates were kept on water bath to obtain the crude extract [ 10 ]. In cotton pellet granuloma test VN extract in graded dosesand mg kg Patel Road, Bilimora, D: In this study, VN extract showed inhibiting effect on oxytocin induced rat uterus contractions in a dose dependent manner. Albino rats of inflamnatory sex were divided into five groups of six animals each.


The tubes were then centrifuged at rpm for 10 min and cooled. Volume of the injected paw was measured plethysmographically immediately after the injection and then again at hourly inflammwtory up to 4h. The present study therefore, intends to investigate the antiinflammatory activity of hydroalcoholic leaves extracts innflammatory polyhedral formulation of Murraya Koenigii and Vitex Negundo on carrageenan induced inflammation in experimental animal models, in order to confirm the medicinal properties of the plant.

Pergamon Press, New York, pp: Please leave a message, we will get back you shortly.

Antioxidant and Antiinflammatory Activity of Vitex negundo.

More over anti-ulcer activity of VN reported by Sahni et al. Confirmation of the antiinflammatory activity in animal models further justifies the traditional use of this plant for inflammatory disorders.

The study was conducted after approval of Institutional Animal Ethical Committee. Wiley Series Chemistry and Pharmacology of Drugs. After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha and Unnani. Gandevi GujaratIndia, Tel: Group I of cotton granulona test receiving distilled water served as diseased control.