BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but there’s still no consensus on treatment. OBJECTIVES. Abstract. Objectives: To evaluate the effect of minocycline as treatment for cutaneous . Calcinosis cutis circumscripta: treatment with intralesional corticosteroid. An year-old woman was followed up for a year history of limited cutaneous systemic sclerosis complicated by recurrent subcutaneous lesions of calcinosis.

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The deposition of calcium in the skin, subcutaneous tissue, muscles and visceral organs is known as calcinosis. This condition commonly occurs in the skin, where it is known as calcinosis cutis or cutaneous calcification.

Calcinosis cutis is classified into four major types. Dystrophic calcinosis cutis occurs in an area where there is damaged, inflamed, neoplastic or necrotic skin. Tissue damage may be from mechanical, chemical, infectious or other factors.

Normal serum calcium and phosphate levels exist. Conditions that can cause dystrophic calcinosis cutis include:.

Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases.

Conditions that can cause metastatic calcinosis cutis include:. Idiopathic calicnosis cutis generally occurs in the absence of any known tissue injury or systemic metabolic defect. Calcification is usually localised to one general area.

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Iatrogenic calcinosis cutis arises secondary to a treatment or procedure, for example parenteral administration of calcium or phosphate, and calcium deposition in newborns from repeated heel sticks. The signs and symptoms of calcinosis cutis vary according to the underlying cause.

In many cases the lesions gradually develop and are often symptomless. A solitary lesion may develop, although multiple lesions are more common.

Calcinosis cutis | DermNet NZ

Lesions may become tender and ulcerate, discharging chalk-like creamy calcnosis consisting mainly of calcium phosphate with a small amount of calcium carbonate.

Fingertip lesions may be painful, while lesions at other sites may restrict joint mobility and limit movement due to stiffening of the skin. In severe cases cutaneous gangrene may occur. Laboratory tests are performed to determine any metabolic abnormalities that may give rise to elevated calcium and phosphate levels.

Radiological examinations including plain film x-ray, CT scanning and bone scintigraphy are useful in demonstrating the extent of tissue calcification. Biopsy of cutaneous lesions is used to calcinozis diagnosis.

Calcinosis Cutis

On histology of calcinosis cutisgranules and deposits of calcium are seen in the dermisoften with a surrounding foreign-body giant cell reaction. Calcium deposits may also be found in subcutaneous tissue. The underlying cause of calcinosis cutis should be identified and treated accordingly. Medical therapy may be used to help relieve symptoms of the condition but are generally of limited and variable benefit.

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Medications that may be tried include corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids. Because surgical trauma may stimulate further calcificationit may be best to excise a small site before going ahead with a large excision. Recurrence is common after excision.

Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases.

Depending on the underlying cause, a multidisciplinary team of physicians including nephrologist, rheumatologist, and haematologist may be needed to manage the condition. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content.

DermNet NZ does not provide an online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.