Published in , the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) sought to determine which of. Request PDF on ResearchGate | On Jul 1, , José Ramón González- Juanatey and others published Después del estudio ALLHAT, ¿qué sabemos de lo que. Después del estudio ALLHAT, ¿qué sabemos de lo que desconocíamos sobre el and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

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Design and Conclusions of the ALLHAT Study

Create a free personal account to access your subscriptions, sign up for alerts, and more. First, the risk of hip and pelvic fractures during in-trial follow-up was lowest in participants assigned to first-step therapy with chlorthalidone compared with amlodipine or lisinopril.

Get free access to newly published articles. No specific funding was allocated for the work presented in this article.

Study concept and design: Given these results and the widespread use of Estudjo for the treatment of hypertension in older adults, our finding has potentially important public health implications. The hypothesis of the ALLHAT study 3 is that the incidence of coronary heart disease would be lower in patients treated with drugs other than diuretics. Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive.

Cumulative fracture rates are shown in Figure 2 B. Bone mineral density changes among women initiating blood pressure lowering drugs: Wright JT, et al.


The groups were equally balanced in all aspects except that in-trial participants randomized to receive chlorthalidone had more baseline CHD than the amlodipine and lisinopril groups Second, analyses that included in-trial and posttrial follow-up yielded a fracture risk that was no longer significantly different between the treatment groups, albeit it was still numerically lowest in the chlorthalidone group. Sign in to save your search Sign in to your personal account.

Estimating equations for glomerular filtration rate in the era of creatinine standardization: Less is known regarding the effects of angiotensin-converting enzyme inhibitors ACEis and calcium channel blockers CCBs on fracture risk despite their ubiquitous use in older adults with hypertension. Hip fracture in patients with non-dialysis-requiring chronic kidney disease [published online May 4, ].

ALLHAT – Wiki Journal Club

We hypothesized fewer in-trial fracture hospitalizations in those randomized to chlorthalidone vs comparators and that this benefit would persist into the posttrial surveillance period when participants were no longer randomized to study medications.

Three of these individuals had both hip and pelvic fractures. The authors outside the Coordinating Center did not have access to participant-level identifying data. Similar trends were found when chlorthalidone use was compared with lisinopril esstudio amlodipine use separately eFigure 1 in the Supplement. However, a higher risk of fracture or lower BMD in ACEi users has not been a wstudio finding, and some studies 1011 report a protective effect of renin angiotensin blockade.

Although randomization is not strictly maintained with edtudio approach, this was done for 2 reasons: Healy; Investigators and Coordinators Canada: In a prospective cohort study 12 of older men from the Osteoporotic Fractures in Men Study, with 4.


They should be preferred for first-step antihypertensive therapy. The large sample size, long follow-up, and randomized therapy provide a unique opportunity to examine post hoc the effects of the major classes of blood pressure—lowering medications on the incidence of hospitalizations for hip and pelvic fractures.

If goal blood pressure was not achieved using the maximum tolerated dose, open-label step 2 reserpine, clonidine, or atenolol or step 3 hydralazine medications could be added.

Estuvio with chlorthalidone 6-year rate, All participants gave written informed consent, and all centers obtained institutional review board approval for the trial.

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Get free access to newly published articles Create a personal account or sign in to: Thiazide diuretics and the risk for hip fracture. But such a reduction is to be expected because we can assume that the incidence of such events would be greater in a group receiving no treatment than in one receiving treatment. But estuxio study does wstudio demonstrate the advantages of some combinations over others because we do not know what combination the patients received and, moreover, the combined drugs were administered in an open-label manner.

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