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Computational fluid dynamics CFD simulations and experimental measurements of laboratory-scale Wurster coating were performed.

Voting is allowed only to logged in users. Granule size was mainly influenced by binder particle size.

Your browser does not allow JavaScript! Javascript is necessary for the proper functioning of this website. The effect of the Wurster gap and fluidizing air flow rate on gas-solidflow was analyzed in both simulations and experiments.

A rather good agreement between the simulated and experimental results was observed and thus it can be assumeed that this particular simulation setup represents a computationally reasonable tool that provides a valuable insight into the Wurster coating tehnologijs due to the impact of two-phase flow properties on the process.

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Galenska farmacija: (Farmacevtska tehnologija I) – Pavle Bohinc – Google Books

The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.

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Binder content was shown to be important for narrow size distribution and goodflow properties. URL – Presentation file, Visit http: Besides the nature and tehnologjia of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. You have to log in to leave a comment.

Javascript is necessary for the proper functioning of this website. CFD simulations were performed in a 2D axisymmetric space using the two-fluid model.

Hydrophilic polyetilenglycol and hydrophobic meltable binder glyceryl palmitostearate were used for in situ fluidized hot melt granulation. URL – Presentation file, Visit http: Experimentally, the draft tube two-phase flow was evaluated by measuring the volume fraction of pellets within the draft tube and local particle velocities at the tube exit and by monitoring the local pressure drop fluctuations.

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Your browser does not allow JavaScript! Please enable JavaScript or use a modern browser. Pellet coating is commonly performed in a fluid bed coater such as a Wurster coater.

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Voting is allowed only to logged in users. Solid state analysis confirmed unaltered physical state of the granulate components and the absenceof interactions between the active and excipients. The results obtained indicate that conventional fluid bedgranulator may be suitable for production of highly spherical agglomerates,particularly when immersion and layering is dominant agglomeration mechanism.

Granule shape was affected by interplay of binder content, binder particle size and granulation time. The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule sizeand size distribution, granule shape and flowability, as well as on drug release rate.